The impact of GST on e-commerce businesses has been significant, bringing more transparency and uniform taxation across India. It has simplified interstate trade but also introduced compliance requirements like TCS and regular return filing. Sellers must stay updated with regulations, and enrolling in GST Training in Chennai (https://www.fita.in/gst-training-in-chennai/) at FITA Academy (https://www.fita.in/) can help them manage taxation efficiently and avoid penalties.